RESUMEN
Objective: To analyze the scientific evidence regarding the effectiveness of using ozone to disinfect surfaces based on an integrative literature review.Methods: A search was carried out in the SciELO, MEDLINE, LILACS, PubMed, Science Direct databases. Eleven articles published January 2010 to August 2021 were analyzed. All employed the experimental laboratory research model and achieved different levels of disinfection by O3, however, with varied surfaces and products tested, in addition to different methodological procedures.Results: The majority had an inhibition rate by O3 equal to or greater than 90%, thus proving the effectiveness of this agent as a surface disinfectant, even with variations in parameter values such as concentration and exposure time, in all selected articles, even those that did not prove the effectiveness of O3.Conclusion: This review shows the inhibitory power that O3 has on different pathogens, even if there are variables in the factors used for this purpose, highlighting it in front of other disinfectants. Thus, it corroborates the composition of surface disinfection protocols and decision-making among managers and committees about sanitizing technologies.
RESUMEN
Solid information on exposure and how to treat COVID-19 in pediatric patients is not yet conclusive in the literature, because of this it is necessary to make a critical analysis of the available data in order to provide common points on the theme in question. This systematic review protocol is registered in PROSPERO (ID: CRD42020181835) and aims through searches in the Databases PubMed, Google Scholar, LILACS and CINAHL, to group the studies published with the theme COVID-19 and pediatric between 2019 and 2020. The MeSH descriptors: COVID-19, child and children will be used in English and Chinese. Observational research, clinical trials and literature reviews will be included, where the study sample was composed of pediatric patients of both sexes aged between 6 and 17 years. The Rayyan QCRI tool® will be used to manage revision data. The analysis of the feasibilities of observational studies will be done by the Loney scale, clinical trials by the Cocharne scale and review studies by the Overview Quality Assessment Questionnaire (OQAQ). The authors intend that the study is completed in the second semester of 2021. The choice of the theme is justified because the results of the future research are useful for the elaboration of public health measures that offer the promotion of effective treatment during the recovery of pediatric patients infected with COVID-19.
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The disease outbreak caused by SARS-CoV-2 continues to rise worldwide, even in countries which have considered it controlled. As new cases appear daily, infecting millions of people and causing thousands of deaths, the current in silico study aims to investigate the imidazolic alkaloids of the species Pilocarpus microphyllus (Jaborandi) as a potential inhibitory activity against the M-pro protease from SARS-CoV-2, since it plays a fundamental role in the processing of polyproteins that are translated from viral RNA. Jaborandi is distributed in some Brazilian biomes, being easily identified, yet little researched, with proven anti-inflammatory, contraceptive, anti-diabetic and gastroprotective activities. In this work, DFT calculation of thermodynamic properties, electrostatic potential surface, frontier molecular orbitals and descriptors of chemical reactivity of imidazolic alkaloids were associated with the use of molecular docking techniques, molecular dynamics and ADMET predictions. One can verify a good reactivity chemistry and energetic stability of epiisopiloturine, epiisopilosine, isopilosine and e pilosine with some residues of amino acids present in the active site of the main protease of COVID-19. In this sense, the results point out to the imidazolic alkaloids of Jaborandi as promising targets for in vitro and in vivo tests, as possible candidates for inhibitors of the enzyme M-pro.
RESUMEN
Objective: to analyze the evolution of the number of confirmed COVID-19 cases in the 30 first days of transmission in the state of Ceara. Methods: ecological study of a temporal series. Measures of position and dispersion were calculated, as well as the coefficient of incidence for the first 30 days. The evolution of the number of cases was compared to the trend of advance of the disease. Results: in the 30th day there were 1,800 confirmed cases, peaking in the 23rd day. This study assumes that the measures implemented in the state started to influence the evolution of the disease in the 26th day after the first confirmed case. The incidence coefficient increased 146.5% between the 21st and the 30th days. Conclusion: the mean number of new cases consistently increased in the period analyzed, suggesting that the epidemic has not yet been controlled in the state, but is decelerating.